The Macfarlane lab is focused on the self-assembly of nanoscopic components as a means of tuning the bulk properties of composite materials. In order to achieve this goal, we are broadly interested in the research areas of soft matter, self-assembly, nanoparticle synthesis, polymer chemistry, and biomaterials.
The nanoscale building blocks we use range from inorganic nanoparticles to synthetic polymers to biomolecules like DNA, and the materials we aim to develop possess interesting optical, chemical, electrical, and mechanical properties. The emergent properties of these structures will have significant impact in energy research via light manipulation (e.g. photonic band gaps or plasmonic metamaterials), electronic device fabrication (e.g. semiconducting substrates or data storage devices), and environmental and medical research (e.g. hydrogels for sustained drug delivery). (Click on Research Area titles for links to more detailed descriptions.)
Research Area #1: A Universal Ligand for Materials by Design
We aim to assemble inorganic nanoparticle superlattices by grafting designer polymer chains to their surfaces, then using supramolecular interactions between polymer chains to control how nanoparticles bind to one another.
Research Area #2: Matrix-Controlled Particle Assembly
In this research, we replace the traditional liquid solvents used as assembly matrices with polymer melts, where the use of a polymer-based matrix serves to both stabilize the structure once assembled and enable the synthesis of new structures that are currently unachievable.
Research Area #3: Hybrid Inorganic/Polymer Hydrogels
Composite hydrogels are synthesized from both flexible and rigid components; individual building block properties (size, shape, rigidity, etc.) are examined as a means of controlling bulk hydrogel mechanical properties for biological applications.
DNA-grafted particles are used to generate ordered superlattices where nanoparticle identity, crystallographic symmetry, and lattice parameters are independently controllable with nanometer-scale precision.